Journal Articles
*Denotes co-first authors †Denotes co-corresponding authors **2023 JCR Impact Factor
2024
42. Monomeric and oligomeric amyloid-β cause distinct Alzheimer’s disease pathophysiological characteristics in astrocytes in human glymphatics-on-chip models, Yslas AR, Park R, Nishimura N, Lee E (2024), Lab on a Chip**. https://doi.org/10.1039/D4LC00287C. PDF (**IF=6.1, Selected as Lab on a Chip HOT article 2024)
41. Piezo1 regulates brain fluid drainage in meningeal lymphatic vessels and alleviates excessive CSF accumulation, Choi D, Park E, Choi J, Lu R, Yu JS, Kim C, Zhao L, Yu J, Nakashima B, Lee S, Singhal D, Scallan J, Zhou B, Koh CJ, Lee E, Hong YK (2024), Nature Neuroscience**. https://doi.org/10.1038/s41593-024-01604-8. PDF (**IF=21.2)
2023
40. Engrailed-1 promotes pancreatic cancer metastasis, Xu J, Roe JS, Lee E, Tonelli C, Somerville T, Yao M, Milazzo J, Tiriac H, Kolarzyk AM, Lee E, Grem J, Lazenby A, Grunkemeyer J, Hollingsworth M, Borowsky AD, Park Y, Vakoc C, Tuveson D, Hwang CI (2023), Advanced Science**. e2308537; doi: 10.1002/advs.202308537. PDF (**IF=14.3)
39. A human initial lymphatic chip reveals distinct mechanisms of primary lymphatic valve dysfunction in acute and chronic inflammation, Kraus SE, Lee E (2023), Lab on a Chip**. https://doi.org/10.1039/D3LC00486D. PDF (**IF 6.1)
38. A 3D biomimetic model of lymphatics reveals cell-cell junction tightening and lymphedema via a cytokine-induced ROCK2/JAM-A complex, Lee E†, Chan SL, Lee Y, Polacheck WJ, Kwak S, Wen A, Nguyen DHT, Kutys ML, Alimperti SA, Kolarzyk, AM, Kwak TJ, Eyckmans J, Bielenberg DR, Chen H, Chen CS† (2023), Proceedings of the National Academy of Sciences (PNAS)**. 120 (41) e2308941120. PDF (**IF 9.4; †Co-corresponding authors)
37. Identification of novel pathogenic roles of BLZF1/ATF6 in tumorigenesis of gastrointestinal stromal tumor showing Golgi-localized mutant KIT, Kwon Y, Kim J, Cho SY, Kang YJ, Lee J, Kwon J, Rhee H, Bauer S, Kim HS, Lee E, Kim HS, Jung JH, Kim H, Kim WK (2023), Cell Death and Differentiation**. https://doi.org/10.1007/s12195-023-00780-0. PDF (**IF 13.7)
36. A 3D human lymphatic vessel-on-chip reveals the roles of interstitial flow and VEGF-A/C for lymphatic sprouting and discontinuous junction formation, Ilan IS, Yslas AR, Peng Y, Lu R, Lee E (2023), Cellular and Molecular Bioengineering (CMBE)**. https://doi.org/10.1007/s12195-023-00780-0. PDF (**2023 CMBE Young Innovators, Biomedical Engineering Society)
35. Microphysiological systems for cancer immunotherapy research and development, Peng Y, Lee E (2023), Advanced Biology. doi: adbi.202300077. PDF
2022
34. A microfluidic model of AQP4 polarization and fluid transport in the healthy and inflamed brain: the first step towards glymphatics-on-a-chip, Soden PA, Henderson AR, Lee E (2022), Advanced Biology**. doi: adbi.202200027. PDF (**Cover Article)
33. Engineering approaches to investigate the roles of lymphatic vessels in rhueumatoid arthritis, Kraus SE, Lee E (2022), Microcirculation. e12769. PDF
32. Tissue engineering in age-related macular degeneration: a mini-review, Wu A*, Lu R*, Lee E (2022), Journal of Biological Engineering**.16;11. PDF (**IF 6.248, Emerging leaders in biological engineering)
31. Lymphatic tissue and organ engineering for in vitro modeling and in vivo regeneration, Kolarzyk AM*, Wong G*, Lee E (2022), Cold Spring Harbor Perspectives in Medicine**. doi: 10.1101/cshperspect.a041169. PDF (**IF 6.915)
: “Angiogenesis” (2nd edition), editors: Patricia D’Amore & Diane Bielenberg
2021
30. A lymphatic co-culture model for personalized cancer medicine, Kolarzyk AM, Lee E (2021), EBioMedicine**. 73;103685. PDF (**IF 9.7)
29. A bioengineered lymphatic vessel model for studying lymphatic endothelial cell-cell junction and barrier function, Henderson AR, Ilan IS, Lee E (2021), Microcirculation**. e12730, https://doi.org/10.1111/micc.12730. PDF (**Cover Article, Top cited article 2021-2022)
28. Comprehensive characterization of distinct genetic alterations in metastatic breast cancer across various metastatic sites, Cha S, Lee E, Won HH (2021), NPJ Breast Cancer**. 7(1):93, Doi: 10.1038/s41523-021-00303-y. PDF (**IF 6.5)
27. Bioengineered in vitro models of leukocyte-vascular interactions, Lee J, Breuer CB, Lee E (2021), Biochemical Society Transactions. BST20200620. PDF
26. Engineering three-dimensional vascularized cardiac tissues, Williams MAC, Mair DB, Lee W, Lee E, Kim DH (2021), Tissue Engineering Part B: Reviews**. 10: 20142. PDF (**IF 5.1)
2020
25. In vitro modeling of tumor spheroid interactions to perfused blood vessels, Kwak T, Lee E (2020), Scientific Reports. 10: 20142. PDF
24. Tissue-engineered models for glaucoma research, Lu R, Soden PA, Lee E (2020), Micromachines (Basel)**. 11(6), 612. PDF **Feature Paper & Editor’s Choice
23. Rapid multilayer microfabrication for modeling organotropic metastasis in breast cancer, Kwak T, Lee E (2020), Biofabrication**. 13: 015002. PDF (**IF 8.2)
22. Blood and lymphatic vasculatures-on-chip platforms and their applications for organ-specific in vitro modeling, Henderson AR*, Choi H*, Lee E (2020), Micromachines (Basel). 11(2), 147. PDF
2019
21. Biomimetic microsystems for blood and lymphatic vascular research, Nguyen DHT, Lee E (2019), Biomimetic Microengineering (CRC Press). page 36-60. PDF
20. A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling, Nguyen DHT*, Lee E*, Alimperti SA, Norgard RJ, Wong A, Lee JJK, Eyckmans J, Stanger BZ, Chen CS (2019), Science Advances**. 5, eaav6789. PDF (**IF 11.7)
Prior to Cornell
19. Biomimetic peptide display from a polymeric nanoparticle surface for targeting and antitumor activity to human triple-negative breast cancer cells. Bressler EM, Kim J, Shmueli RB, Mirando AC, Bazzazi H, Lee E, Popel AS, Pandey NB, Green JJ (2018), Journal of Biomedical Materials Research A. 106(6):1753-1764. PDF
18. Human organ chip models recapitulate orthotopic lung cancer growth, therapeutic responses, and tumor dormancy in vitro. Hassell BA, Goyal G, Lee E, Sontheimer-Phelps A, Levy O, Chen CS, Ingber DE (2018), Cell Reports**. 21(2):508-516. PDF (**IF 7.5)
17. Laminar flow downregulates Notch activity to promote lymphatic sprouting. Choi D, Park E, Jung E, Seong YJ, Yoo J, Lee E, Hong M, Lee S, Ishida H, Burford J, Peti-Peterdi J, Adams RH, Srikanth S, Gwack Y, Chen CS, Vogel HJ, Koh CJ, Wong AK, Hong YK (2017), Journal of Clinical Investigation**. 127(4):1225-1240. PDF (**IF 13.3)
16. Biomimetic on-a-chip platforms for studying cancer metastasis, Lee E, Song HG, Chen CS (2016), Current Opinion in Chemical Engineering**. 11:20-27. PDF (**IF 8.0)
15. The Angiogenic Secretome in VEGF overexpressing Breast Cancer Xenografts. Dore-Savard L, Lee E, Kakkad S, Popel AS, Bhujwalla ZM (2016), Scientific Reports. 6:39460. PDF
14. Crosstalk between cancer cells and blood endothelial and lymphatic endothelial cells in tumor and organ microenvironment. Lee E, Pandey NB, Popel AS (2015), Expert Reviews in Molecular Medicine. 17:e3. PDF
13. Analysis of gene expression of secreted factors associated with breast cancer metastases in breast cancer subtypes. Fertig EJ*, Lee E*, Pandey NB, Popel AS (2015), Scientific Reports. 5:12133. PDF
12. Vasculature-specific MRI reveals differential anti-angiogenic effects of a biomimetic peptide in an orthotopic breast cancer model. Kim E, Lee E, Plummer C, Gil S, Popel AS, Pathak AP (2015), Angiogenesis**. 18(2):125-36. PDF (**IF 9.2)
11. Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis. Lee E, Fertig EJ, Jin K, Sukumar S, Pandey NB, Popel AS (2014), Nature Communications**. 5:4715. PDF (**IF 14.7)
10. Inhibition of breast cancer growth and metastasis by a biomimetic peptide. Lee E, Lee SJ, Koskimaki JE, Han Z, Pandey NB, Popel AS (2014), Scientific Reports. 4:7139. PDF
9. Lymphatic endothelial cells support tumor growth in breast cancer. Lee E, Pandey NB, Popel AS (2014), Scientific Reports. 4:5853. PDF
8. Pre-treatment of mice with tumor-conditioned media accelerates metastasis to lymph nodes and lungs: a new spontaneous breast cancer metastasis model. Lee E, Pandey NB, Popel AS (2014), Clinical & Experimental Metastasis. 31(1):67-79. PDF
7. Angiogenesis interactome and time course microarray data reveal the distinct activation patterns in endothelial cells. Chu LH, Lee E, Bader JS, Popel AS (2014), PLoS One. 9(10):e110871. PDF
6. A biomimetic collagen derived peptide exhibits anti-angiogenic activity in triple negative breast cancer. Rosca EV, Penet MF, Mori N, Koskimaki JE, Lee E, Pandey NB, Bhujwalla ZM, Popel AS (2014), PLoS One. 9(11):e111901. PDF
5. Inhibition of lymphangiogenesis and angiogenesis in breast tumor xenografts and lymph nodes by a peptide derived from transmembrane protein 45A. Lee E, Koskimaki JE, Pandey NB, Popel AS (2013), Neoplasia**. 15(2):112-24.PDF (**IF 6.3)
4. Synergy between a collagen IV mimetic peptide and a somatotropin-domain derived peptide as angiogenesis and lymphangiogenesis inhibitors. Koskimaki JE*, Lee E*, Chen W, Rivera CG, Rosca EV, Pandey NB, Popel AS (2013), Angiogenesis**. 16 (1), 159-170. PDF (**IF 9.2)
3. Serpin-derived peptides are antiangiogenic and suppress breast tumor xenograft growth. Koskimaki JE, Rosca EV, Rivera CG, Lee E, Chen W, Pandey NB, Popel AS (2012), Translational Oncology. 5(2):92-7. PDF
2. Small peptides derived from somatotropin domain-containing proteins inhibit blood and lymphatic endothelial cell proliferation, migration, adhesion, and tube formation. Lee E*, Rosca EV*, Pandey NB, Popel AS (2011), International Journal of Biochemistry & Cell Biology. 43(12):1812-21. PDF
1. Polyproline-type helical-structured low-molecular-weight heparin (LMWH)-taurocholate conjugate as a new angiogenesis inhibitor. Lee E*, Kim YS*, Bae SM, Kim SK, Jin S, Chung SW, Lee M, Moon HT, Jeon OC, Park RW, Kim IS, Byun Y, Kim SY (2009), International Journal of Cancer**. 124(12):2755-65. PDF (**IF 5.7)
Patents
3. Selective ROCK2 inhibition for treatment of edema and associated conditions. E Lee, CS Chen (2022), WO2022169946A1; Application PCT/US2022/015072.
2. Biomimetic peptide and biodegradable delivery platform for the treatment of angiogenesis and lymphangiogenesis-dependent diseases. AS Popel, NB Pandey, E Lee, JJ Green, RB Shmueli (2017), US Patent 9,802,984.
1. Heparin conjugates and methods. Y Byun, ES Lee, O Jeon, SY Kim, RW Park (2012), US Patent 8,088,753.