We look for a highly motivated postdoctoral fellow (this position will be supported by an NIH R01 grant). We broadly study vascular and lymphatic biology, cancer biology, immunology, and regenerative medicine by employing 3D tissue engineering, organs-on-chip, organoids in vitro platforms, molecular biology methods, and in vivo animal models. Below is the expertise we seek, but it can be flexible based on the candidate’s background and interest.
- Designing, fabrication (soft lithography), and characterization of microfluidic devices, lab-on-chip, organ-on-chip, 3D cellularity, tissue level in vitro modeling
- Cell seeding, cell culturing & maintaining on-chip; and investigating cell mechanics, cell-cell interactions, cell secretome, cell morphology on-chip
- Experience in developing tissue-level 3D mono/multi-cellular structure in vitro is a plus.
- Experience in organoids, stem cells, multicellular behaviors, and cells in shear stress is a plus.
- To deepen the understanding of blood and lymphatic vascular morphogenesis, homeostasis, and pathogenesis.
- Purification, maintaining, and culturing of human blood/lymphatic vascular endothelial cells and vascular mural cells (pericytes, smooth muscle cells, etc.) using animal and human samples.
- Monitoring vascular morphology and function in vitro and in vivo.
- Monitoring tumor/immune cell interactions to vasculatures in vitro and in vivo.
- Expertise in vivo implantation of engineered tissues is a plus.
- Expertise in vascular disease animal models in vivo (lymphedema, hypertension, vascular leakage, etc.) is a plus.
- To deepen our understanding of adaptive immunity and lymph node/lymphoid organ biology
- Purification, adaptation, activation, and FACS characterization of immune cells (dendritic cells, T/B lymphocytes) obtained from animal and human samples.
- Monitoring immunity in vitro and in vivo.
- Modeling systemic/local infections in animal models and in vitro models.
- In vivo imaging (live or fixed samples) of immune cells and lymphoid organs in mice.
- Expertise in cancer immunology, lymph nodes, and lymphoid organs is a plus.
- To apply the organoid technologies to host immunity, vascular, lymphatic, cancer, and organ regenerative medicine
- iPSCs differentiation to specific cell types (e.g., liver, gut, brain, heart, endothelial cells, pericytes, etc.).
- Monitoring and characterizing organoid development in vitro and in vivo.
- To deepen our understanding of tumor initiation, progression, and interactions with blood and lymphatic vascular structures
- Knowledge of the mechanobiology of epithelial tumor cells is a plus
- Monitoring tumor interactions to vasculature in vitro and in vivo.
- Tumor immunotherapy, tumor metabolism, tumor metastasis, resistance.
How to apply:
Send your cover letter and current CV that includes your degree information, publications, and the list of 3 references to Dr. Lee (firstname.lastname@example.org).
Cornell University is an innovative Ivy League university and a great place to work. Our inclusive community of scholars, students and staff contribute creative ideas to further the university’s mission of teaching, discovery, and engagement. The main campus in Ithaca sits at the southern tip of Cayuga Lake in the Finger Lakes region of New York State. The Ithaca area offers a small-town lifestyle with the cultural and culinary qualities of larger cities, including the Moosewood Restaurant known for the first vegetarian cookbook. The climate of the region provides for a range of outdoor activities including boating/sailing, swimming, mountain biking and hiking in summer, to skiing and ice skating in winter.
The Meinig School of Biomedical Engineering is located in the College of Engineering on Cornell’s main campus in Ithaca, New York, with strong collaborative ties to the College of Veterinary Medicine in Ithaca, and Weill Cornell Medicine in New York City. Our global presence includes College of Medicine campuses in Manhattan and Doha, Qatar, and the Cornell Tech campus on Roosevelt Island in New York City.
Fundamental and applied research, and translational development are supported by an extensive network of centers and institutes (https://research.cornell.edu/content/centers-institutes-programs- laboratories) including the Cornell Center on the Physics of Cancer Metabolism, Cornell Neurotechnology NeuroNex Hub, Cornell Center for Materials Research, Cornell Nanoscale Facility, Kavli Institute at Cornell for Nanoscale Science, and the Kevin M. McGovern Family Center for Venture Development in the Life Sciences.