We aim to understand the morphogenesis, homeostasis, and disease pathogenesis of lymphatic vessels and blood vessels and their microenvironments to provide new strategies for regenerative medicine and treatment of immune diseases, cancer, and edema. To this end, we are working to develop novel three-dimensional (3D) organ-on-chip systems, cellular and molecular tools, and in vivo models to better understand the mechanisms by which cells regulate and respond to biological and mechanical cues.


Recent News

April 22, 2024:


April 16, 2024:

Dr. Lee is the recipient of the NSF Career Award! The NSF award will support our research and education on breast cancer-related secondary lymphedema. 

Cornell BME News: “Esak Lee awarded NSF CAREER grant for lymphedema in breast cancer research”


April 5, 2024:  

Big congratulations to Dr. Renhao Lu for successfully defending his dissertation! Being the first Ph.D. in the Lee lab, Renhao’s research on “Tissue-Engineered In Vitro Models for Studying Lymphatic Morphogenesis, Pathogenesis, and Drug Delivery” sets a remarkable precedent! 


March 25, 2024:

Check out our collaborative work with Dr. Young-Kwon Hong from USC, published in Nature Neuroscience! In this study, Renhao demonstrated how Piezo1 controls fluid drainage using lymphatics-on-chip, offering a new idea to address excessive CSF buildup in the brain! 



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To create and nurture a diverse community dedicated to the discovery, scholarship, and leadership to improve human health and wellness by taking principles from engineering, biology, and medicine” – Lee lab mission.